反应详情

温度

100 °C

A 70 mL stainless steel high pressure reactor having a Pyrex glass liner nd a magnetic stir bar was charged with 5 mL of tetrahydrofuran, 0.5 mmol of n-pentadecane internal standard, 0.5 mmol of CH3OH, 45.8 mg of (PPh3)2PdCl2, and 53.3 mg of N-acetyl-2-pyrroline. The reactor was pressurized with 700 psi of CO and 300 psi of H2 at room temperature, and the reaction mixture was stirred at 100° C. for 18 hours. Thereafter, the reactor was cooled to room temperature and vented to atmospheric pressure. The product mixture was analyzed by gas chromatography, and the analysis indicated 99.0% conversion of N-acetyl-2-pyrroline. The reactor was pressurized with 700 psi of CO and 300 psi of H2 at room temperature, and the reaction mixture was stirred at 100° C. for 18 hours. Thereafter, the reactor was cooled to room temperature and vented to atmospheric pressure. The product mixture was analyzed by gas chromatography, and the analysis indicated 99.0% conversion of N-acetyl-2-pyrroline and 18.5% yield of N-acetylproline methyl ester.

1. customA 70 mL stainless steel high pressure reactor having
2. customwas pressurized with 700 psi of CO and 300 psi of H2 at room temperature
3. temperatureThereafter, the reactor was cooled to room temperature
4. customwas pressurized with 700 psi of CO and 300 psi of H2 at room temperature
5. stirringthe reaction mixture was stirred at 100° C. for 18 hours
6. temperatureThereafter, the reactor was cooled to room temperature