1-Chloro-2-propanol → 1-Methyl-2-[4-(3,5-difluorophenoxy)phenoxy]ethanol

HRID 579952Notes

Reaction equation

HRID 579952 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:13]=[C:14]([F:16])[CH:15]=1)[O:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.[O-]CC.[Na+].[Na].Cl[CH2:23][CH:24]([OH:26])[CH3:25]>C(O)C>[CH3:23][CH:24]([OH:26])[CH2:25][O:12][C:9]1[CH:8]=[CH:7][C:6]([O:5][C:4]2[CH:3]=[C:2]([F:1])[CH:15]=[C:14]([F:16])[CH:13]=2)=[CH:11][CH:10]=1

Participants

6

Reactant 4

HCID 313701-Chloro-2-propanolHCID 2723922Sodium ethoxideHCID 5360545SodiumHCID 133918364-(3,5-Difluorophenoxy)phenol

Product 1

HCID 134559131-Methyl-2-[4-(3,5-difluorophenoxy)phenoxy]ethanolYield 59.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-(3,5-Difluorophenoxy)phenol (3.0 g, 13.5 mmol) was added to an ethanolic solution of sodium ethoxide prepared from ethanol (15 ml) and sodium (313 mg, 13.6 mmol). To the resultant solution, 1-chloro-2-propanol (1.60 g, 16.9 mmol) was dropwise added with stirring under reflux. After completion of the addition, the resultant mixture was stirred under reflux for 5 hours. After allowed to cool, ethanol was removed, and the residual oil was dissolved in toluene. The toluene layer was washed with water once, a 20% aqueous potassium hydroxide solution two times and a saturated aqueous sodium chloride solution once in order and dried over anhydrous magnesium sulfate. Removal of the solvent gave 1-methyl-2-[4-(3,5-difluorophenoxy)phenoxy]ethanol (2.24 g).

Workup

  1. temperatureunder reflux
  2. additionAfter completion of the addition
  3. temperatureunder reflux for 5 hours
  4. temperatureto cool
  5. customethanol was removed
  6. dissolutionthe residual oil was dissolved in toluene
  7. washThe toluene layer was washed with water once
  8. dry with materiala 20% aqueous potassium hydroxide solution two times and a saturated aqueous sodium chloride solution once in order and dried over anhydrous magnesium sulfate
  9. customRemoval of the solvent

Sources & evidence

ORD record
ord-d0708e4be81b410e9ae01c09bf8b9dff
Source dataset
uspto-grants-1988_06
Patent number
US04751225

Reaction notes

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