Formaldehyde → 3-[(3-Hydroxypropyl)amino]propanenitrile

HRID 580028Notes

Reaction equation

HRID 580028 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].[C:6](#[N:9])[CH:7]=[CH2:8].C=O.C#N.C=O.C#N.S([O-])(O)=O>>[C:6]([CH2:7][CH2:8][NH:1][CH2:2][CH2:3][CH2:4][OH:5])#[N:9]

Participants

7

Reactant 6

HCID 712FormaldehydeHCID 768Hydrogen CyanideHCID 7855AcrylonitrileHCID 90863-Amino-1-propanolHCID 104748BisulfiteHCID 86742226HCID 86742226, compound

Product 1

HCID 135569403-[(3-Hydroxypropyl)amino]propanenitrile

Procedure

75 grams (1 mole) of 3-amino-propanol were treated with 53 grams (1 mole) of acrylonitrile within one hour at 25° C. The mixture was allowed to react further for 1 hour at 40° C. The thus obtained reaction product (128 grams) was directly reacted further with formaldehyde/hydrocyanic acid or formaldehyde/alkali salt of hydrocyanic acid in the presence of alkali hydrogen sulfite.

Workup

  1. customto react further for 1 hour at 40° C

Sources & evidence

ORD record
ord-0280d27fa4724f99931795ea94bea3bf
Source dataset
uspto-grants-1988_06
Patent number
US04751298

Reaction notes

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