反应详情

To a solution of Compound XXV (15.94 g; 72.7 mmole) in 100 ml of pyridine was added triphenylphosphine (29 g; 111 mmole). After stirring for one hour, at which time gas evolution had subsided, 50 ml of concentrated aqueous ammonium hydroxide was added and the mixture stirred overnight. The reaction mixture was concentrated under vacuum and the residue partitioned between 200 ml of water and 200 ml of ether (aqueous layer at pH 2). The aqueous layer was washed twice with 200 ml ether each time. The aqueous layer was adjusted to pH 11 with solid sodium hydroxide and extracted three times with 150 ml n-butanol each time. The butanol extract was dried over sodium sulfate, filtered and concentrated. The residue was taken up in tetrahydrofuran and filtered. The filtrate was evaporated to a syrup which was azeotroped with toluene.

1. stirringthe mixture stirred overnight
2. concentrationThe reaction mixture was concentrated under vacuum
3. customthe residue partitioned between 200 ml of water and 200 ml of ether (aqueous layer at pH 2)
4. washThe aqueous layer was washed twice with 200 ml ether each time
5. extractionextracted three times with 150 ml n-butanol each time
6. extractionThe butanol extract
7. dry with materialwas dried over sodium sulfate
8. filtrationfiltered
9. concentrationconcentrated
10. filtrationfiltered
11. customThe filtrate was evaporated to a syrup which
12. customwas azeotroped with toluene