Hydrochloric Acid → 1-(3-Diethylaminopropyl)-3-(3-diethylaminopropylamino)-5-aminoindazole trihydrochloride

HRID 580153Notes

Reaction equation

HRID 580153 reaction equation
[CH2:1]([N:3]([CH2:26][CH3:27])[CH2:4][CH2:5][CH2:6][N:7]1[C:15]2[C:10](=[CH:11][C:12]([NH2:16])=[CH:13][CH:14]=2)[C:9]([NH:17][CH2:18][CH2:19][CH2:20][N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])=[N:8]1)[CH3:2].[ClH:28].C(OCC)C>C(O)C>[ClH:28].[ClH:28].[ClH:28].[CH2:26]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][N:7]1[C:15]2[C:10](=[CH:11][C:12]([NH2:16])=[CH:13][CH:14]=2)[C:9]([NH:17][CH2:18][CH2:19][CH2:20][N:21]([CH2:22][CH3:23])[CH2:24][CH3:25])=[N:8]1)[CH3:27]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 201358371-(3-Diethylaminopropyl)-3-(3-diethylaminopropylamino)-5-aminoindazole

Product 1

HCID 201358791-(3-Diethylaminopropyl)-3-(3-diethylaminopropylamino)-5-aminoindazole trihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 15 ml of absolute ethyl alcohol was dissolved 0.7 g of the 1-(3-diethylaminopropyl)-3-(3-diethylaminopropylamino)-5 -aminoindazole, and into the solution was introduced dried hydrogen chloride gas under cooling with ice. Then to the solution was added anhydrous diethyl ether to separate crystals. The crystals were obtained by filtration and dried to give 1-(3-diethylaminopropyl)-3-(3-diethylaminopropylamino)-5-aminoindazole trihydrochloride having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThe crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-933d3d0c3b2447ef8b3a15d27e08d147
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

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