反应详情

温度

80 °C

Into a 250 ml round bottom flask are placed 26 g (0.47 mole) of propargylamine, 78.8 g (0.47 mole) of methyl 2-bromopropionate, and 39.7 g (0.47 mole) of sodium bicarbonate. The reaction mixture is heated at 80° C. overnight. It is cooled and poured into 200 ml of water. Extraction with ether provides 45 g of crude product which is further purified by vacuum distillation (94°-95°/3 mm) to give 25 g of desired product.

1. customInto a 250 ml round bottom flask are placed
2. temperatureIt is cooled
3. extractionExtraction with ether
4. customprovides 45 g of crude product which
5. distillationis further purified by vacuum distillation (94°-95°/3 mm)