反应详情

To a mixture of 10 g (0.18 mole) of allylamine, 10.8 g (0.2 mole) of sodium bicarbonate in 50 ml of ethanol is added 30 g (0.18 mole) of methyl 2-bromopropionate dropwise. The resulting mixture is heated under reflux for 5 hours. The reaction mixture is cooled, poured into water, and extracted with ether. The combined ether extracts are washed with water and dried over magnesium sulfate. The drying agent is filtered and the filtrate is concentrated under reduced pressure to give 15.5 g of a light yellow oil. This material is further purified by distillation to give 10.5 g of pure product.

1. temperatureThe resulting mixture is heated
2. temperatureunder reflux for 5 hours
3. temperatureThe reaction mixture is cooled
4. extractionextracted with ether
5. washThe combined ether extracts are washed with water
6. dry with materialdried over magnesium sulfate
7. filtrationThe drying agent is filtered
8. concentrationthe filtrate is concentrated under reduced pressure