HCID 54365084, compound → HCID 86742243, compound

HRID 580514Notes

Reaction equation

HRID 580514 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH:15]=[C:16]([N+:20]([O-:22])=[O:21])[C:17](=O)[CH3:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:23][C:24]([F:46])([F:45])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[CH2:31][CH2:32][N:33]1[CH2:38][CH2:37][N:36]([C:39](=[O:44])/[CH:40]=[C:41](\[NH2:43])/[CH3:42])[CH2:35][CH2:34]1>C(O)(C)C>[F:46][C:24]([F:23])([F:45])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[CH2:31][CH2:32][N:33]1[CH2:34][CH2:35][N:36]([C:39]([C:40]2[CH:15]([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[O:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:16]([N+:20]([O-:22])=[O:21])=[C:17]([CH3:18])[NH:43][C:41]=2[CH3:42])=[O:44])[CH2:37][CH2:38]1

Participants

4

Reactant 2

HCID 54365084HCID 54365084, compoundHCID 86742244HCID 86742244, compound

Product 1

HCID 86742243HCID 86742243, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2.97 g (10 mmol) of 1-(-2-benzyloxyphenyl)-2-nitro-1-buten-3-one and 2.96 g (mmol) of 3-aminocrotonic acid 4-(2-trifluoromethylphenylethyl)piperazide are heated in 15 ml of isopropanol at 60° C. for 4 hours. After cooling, a crude product is obtained, and this is recrystallized from a littel ethanol.

Workup

  1. temperatureAfter cooling

Sources & evidence

ORD record
ord-452d18c95e5c48fa949bbd6afed65a68
Source dataset
uspto-grants-1988_06
Patent number
US04753936

Reaction notes

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