Ammonium Hydroxide → HCID 13282892, compound

HRID 580549Notes

Reaction equation

HRID 580549 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH:12]([OH:18])[C:13](OCC)=[O:14])[CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2.[OH-].[NH4+:20]>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH:12]([OH:18])[C:13]([NH2:20])=[O:14])[CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 13560092Ethyl 2-(6-fluoro-8-quinolyl)-2-hydroxyacetate

Product 1

HCID 13282892HCID 13282892, compound

Procedure

Ethyl 2-(6-fluoro-8-quinolyl)-2-hydroxyacetate (1.1 g.) was refluxed for 10 minutes in 300 ml. of conc. ammonium hydroxide. The reaction mixture was cooled slightly, clarified by filtration and evaporated to solids. Trituration of the residue with 25 ml. of toluene gave the title product (860 mg., m.p. 169°-171° C.).

Workup

  1. temperatureThe reaction mixture was cooled slightly
  2. filtrationclarified by filtration
  3. customevaporated to solids

Sources & evidence

ORD record
ord-67bb7d5391e04f7281a160aaad107862
Source dataset
uspto-grants-1988_06
Patent number
US04753956

Reaction notes

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