反应详情

65.96 g (355.7 mmol) of α-bromobutyric acid chloride is added in drops at 0° C. to 100 g (296.4 mmol) of glycine benzyl ester p-toluenesulfonic acid salt and 89.98 g (889.2 mmol) of triethylamine in 500 ml of methylene chloride. In this case, the temperature remains between 0° C.-5° C. 1000 ml of 5% aqueous hydrochloric acid is added, and the organic phase is separated. The organic phase is extracted once more with 500 ml of 5% aqueous hydrochloric acid, dried on magnesium sulfate and evaporated to dryness in a vacuum. The residue is recrystallized from diisopropyl ether.

1. customremains between 0° C.-5° C
2. customthe organic phase is separated
3. extractionThe organic phase is extracted once more with 500 ml of 5% aqueous hydrochloric acid
4. customdried on magnesium sulfate
5. customevaporated to dryness in a vacuum
6. customThe residue is recrystallized from diisopropyl ether