反应详情

To a solution of 3-(2-fluoropyridin-3-yl)-4-(2-ethylaminopyridin-3-yl)thiophene (0.021 g) in tetrahydrofuran (1.5 mL was added potassium bistrimethylsilylamide (0.5M in toluene) until no yellow color appeared on addition of further reagent. The mixture was stirred for 5 minutes, ethanol was added, the mixture was diluted with ethyl acetate, washed with water, dried, filtered and evaporated. The residue was fractionated by chromatography to give 8-ethyl-thienyl[3',4':6,5]dipyrido[2,3-b:3',2'-f]azepine mp 140-142° C.

1. additionappeared on addition of further reagent
2. washwashed with water
3. customdried
4. filtrationfiltered
5. customevaporated