反应详情

温度

60 °C

3.35 g of 5,6,7,8-tetrahydro-2-phenylimidazo[2,1-b]benzothiazole was suspended in 20 ml of dimethylformamide. To the resultant mixture, 3 ml of phosphorus oxychloride was added dropwise at 0° C. over 10 minutes. The solution was gradually returned to room temperature, then heated and stirred at 60° C. for 3 hours, poured onto an aqueous sodium carbonate solution, then extracted with chloroform. The solvent was distilled off, the residue was then recrystallized from ethanol to obtain the desired substance in an amount of 2.31 g (yield of 82.0%) (melting point:150-150.5° C.).

1. customwas gradually returned to room temperature
2. temperatureheated
3. extractionextracted with chloroform
4. distillationThe solvent was distilled off
5. customthe residue was then recrystallized from ethanol
6. customto obtain the desired substance in an amount of 2.31 g (yield of 82.0%) (melting point:150-150.5° C.)