反应详情

34.3 g (0.19 mol) of 2-amino-6-methoxy-benzothiazole and 140 g (2.5 mol) of 85% potassium hydroxide are refluxed in 350 ml of water for 5 hours. Then the mixture is cooled and neutralised with 200 ml of concentrated hydrochloric acid. The mixture is stirred for a further 30 minutes, the precipitate formed is suction filtered, washed with water and dried in vacuo. Yield: 24.0 g (81.4% of theory). The following is obtained analogously to Example B:

1. temperatureThen the mixture is cooled
2. customthe precipitate formed
3. filtrationfiltered
4. washwashed with water
5. customdried in vacuo
6. customThe following is obtained analogously to Example B