Methylamine → HCID 53975194, compound

HRID 581057Notes

Reaction equation

HRID 581057 reaction equation
Br[CH2:2][CH2:3][O:4][C:5]1[CH:22]=[CH:21][C:8]2[N:9]=[C:10]([S:12][CH2:13][C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)[S:11][C:7]=2[CH:6]=1.[CH3:23][NH2:24]>>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([CH2:13][S:12][C:10]2[S:11][C:7]3[CH:6]=[C:5]([O:4][CH2:3][CH2:2][NH:24][CH3:23])[CH:22]=[CH:21][C:8]=3[N:9]=2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 54431103HCID 54431103, compound

Product 1

HCID 53975194HCID 53975194, compoundYield 97.5%

Procedure

Prepared from 6-(2-bromoethoxy)-2-(4-chlorobenzyl-mercapto)-benzothiazole and methylamine analogously to Example 3. Yield: 97.5% of theory, Melting point: 56-58° C., 1H-NMR spectrum (200 MHz, CDCl3, signals at ppm): 1.56 (s, 1H); 2.52 (s, 3H); 3.0 (t, 2H); 4.22 (t, 2H); 4.51 (s, 2H); 7.03 (dd, 1H); 7.23 (d, 1H); 7.33 (AB, 4H); 7.77 (d, 1H).

Sources & evidence

ORD record
ord-2e163370a6a044dbb37a61ff9290996d
Source dataset
uspto-grants-1999_07
Patent number
US05919807

Reaction notes

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