Piperazine → 1-(Tetrahydro-2-furoyl)piperazine

HRID 581188Notes

Reaction equation

HRID 581188 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[O:7]1[CH2:11][CH2:10][CH2:9][CH:8]1[C:12](O)=[O:13]>>[O:7]1[CH2:11][CH2:10][CH2:9][CH:8]1[C:12]([N:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1)=[O:13]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 86079(+-)-Tetrahydro-2-furoic acid

Product 1

HCID 27346411-(Tetrahydro-2-furoyl)piperazineYield 46%

Procedure

A suspension of piperazine (7.23 g, 0.084 mol) in xylenes (50 mL) was added tetrahydro 2-furanoic acid (4.85 g, 0.042 mol). The mixture was heated to reflux for 28 hours. The reaction mixture was cooled to room temperature and filtered. The filtrate was concentrated to give 3.53 g of product (46% yield).

Workup

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 28 hours
  3. filtrationfiltered
  4. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-0b687bb48bd8488cb6893061ac1b7516
Source dataset
uspto-grants-1999_07
Patent number
US05919931

Reaction notes

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