反应详情

To a solution of 6-chloro-N-methylpyrimidin-4-amine (Procedure 2A, step e; 460 g, 3.21 mmol) in DMF (15 mL) was added NaH (60%, 193 g, 4.81 mmol) at 0° C., and the mixture was stirred for 30 minutes at room temperature. A solution of 2,4-dichloro-3-isocyanato-1,5-dimethoxy-benzene (Procedure H, steps a-d; 1.03 g, 4.17 mmol) in DMF (5 mL) was added dropwise at room temperature. The resulting mixture was stirred for 0.5 hour. SEMCl (804 g, 4.81 mmol) in DMF (2 mL) was added. The reaction mixture was stirred at room temperature for 1 hour. Saturated aqueous NH4Cl was added to quench the reaction. The mixture was diluted with water and extracted with EtOAc. The combined extracts were washed with water and brine, dried over anhydrous Na2SO4 and filtered. The filtrate was evaporated under vacuum to give crude product, which was purified by flash chromatography on silica to obtain the title compound (470 mg, yield: 28%). MS (ESI): 521 [M+H]+.

1. stirringThe resulting mixture was stirred for 0.5 hour
2. stirringThe reaction mixture was stirred at room temperature for 1 hour
3. customto quench
4. customthe reaction
5. extractionextracted with EtOAc
6. washThe combined extracts were washed with water and brine
7. dry with materialdried over anhydrous Na2SO4
8. filtrationfiltered
9. customThe filtrate was evaporated under vacuum
10. customto give crude product, which
11. customwas purified by flash chromatography on silica