反应详情

To a solution of 4,6-dichloro-pyrimidine (1 g, 7 mmol) in iPrOH (40 mL) and DIPEA (1.16 g, 9 mmol) was added a solution of 2-pyridinylmethanamine (970 g, 9 mmol) at room temperature. The resulting mixture was stirred at room temperature for 2.5 hours. Water was added and the mixture was extracted with DCM. The combined extracts were washed with brine, dried over anhydrous sodium sulfate and concentrated to give a crude product, which was purified by flash chromatography on silica to obtain the title compound (1.2 g, yield: 78%). MS (ESI): 221 [M+H]+.

1. extractionthe mixture was extracted with DCM
2. washThe combined extracts were washed with brine
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationconcentrated
5. customto give a crude product, which
6. customwas purified by flash chromatography on silica