Hydrochloric Acid → 4-(2-Chlorophenyl)-4-cyanopiperidine hydrochloride

HRID 581806Notes

Reaction equation

HRID 581806 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1([C:22]#[N:23])[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1>CCOC(C)=O>[ClH:2].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1([C:22]#[N:23])[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21712251Tert-butyl 4-(2-chlorophenyl)-4-cyanopiperidine-1-carboxylate

Product 1

HCID 223792744-(2-Chlorophenyl)-4-cyanopiperidine hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of EtOAc saturated with HCl (200 ml) was added to 4-(2-chlorophenyl)-4-cyano-N-(1,1-dimethylethoxycarbonyl)piperidine, (880 mg, 2.74 mmol). The resulting mixture was allowed to react for 1 hour at room temperature. The EtOAc was removed in vacuo affording 4-(2-Chlorophenyl)-4-cyanopiperidine hydrochloride (4j) as a white solid.

Workup

  1. customto react for 1 hour at room temperature
  2. customThe EtOAc was removed in vacuo

Sources & evidence

ORD record
ord-296ca391642b4f318c76245804f2623c
Source dataset
uspto-grants-1999_07
Patent number
US05922722

Reaction notes

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