Diisopropylethylamine → 4-Benzyl-2-cyano-1-phenylpiperazine

HRID 581809Notes

Reaction equation

HRID 581809 reaction equation
Cl.[CH2:2]([NH:9][CH2:10][CH2:11][NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH:19]([N:22](C(C)C)CC)(C)C.[C:28]([C:30](=C)C#N)#N>CN(C=O)C>[CH2:2]([N:9]1[CH2:30][CH2:28][N:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:11]([C:19]#[N:22])[CH2:10]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 136705Vinylidene cyanideHCID 12366334N1-Benzyl-N2-phenylethane-1,2-diamine hydrochloride

Product 1

HCID 149987524-Benzyl-2-cyano-1-phenylpiperazine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 14 (5.07 g, 17.0 mmol) and diisopropylethylamine (4.97 g, 38.4 mmol) in DMF (40 nL) was treated with a solution of 2-cyanoacrylonitrile (2.30 g, 26.3 mmol) in DMP (40 mL) at room temperature (14 d). The solvent was removed in vacuo and the residue dissolved in dichloromethane and washed with water, brine, and dried (Na2SO4). Concentrated in vacuo, the residue was recrystallized from ethanol to afford 15 as white crystals.

Workup

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue dissolved in dichloromethane
  3. washwashed with water, brine
  4. dry with materialdried (Na2SO4)
  5. concentrationConcentrated in vacuo
  6. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-d673e83997664fb0bb5750196b09c9a1
Source dataset
uspto-grants-1999_07
Patent number
US05922722

Reaction notes

Loading…