Water → HCID 10991979, compound

HRID 581813Notes

Reaction equation

HRID 581813 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]2[N:12]=[C:11](Cl)[CH:10]=[C:9]([Cl:14])[N:8]=2)=[CH:4][CH:3]=1.[Cl:15][C:16]1[CH:21]=[C:20]([OH:22])[CH:19]=[CH:18][N:17]=1.C(=O)([O-])[O-].[K+].[K+].O>C(#N)C>[Cl:1][C:2]1[S:6][C:5]([C:7]2[N:8]=[C:9]([Cl:14])[CH:10]=[C:11]([O:22][C:20]3[CH:19]=[CH:18][N:17]=[C:16]([Cl:15])[CH:21]=3)[N:12]=2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 11032782HCID 11032782, compoundHCID 178516507HCID 178516507, compound

Product 1

HCID 10991979HCID 10991979, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

0.4 g 2-(5-Chloro-2-thienyl)-4,6-dichloropyrimidine, 0.2 g 2-Chloro-4-hydroxypyridine, and 0.3 g potassium carbonate are refluxed in 30 mL dry acetonitrile for 16 hours. The mixture is poured into water, and the product is extracted with toluene and purified by flash chromatography (0.38 g, m.p. 154-156° C.).

Workup

  1. extractionthe product is extracted with toluene
  2. custompurified by flash chromatography (0.38 g, m.p. 154-156° C.)

Sources & evidence

ORD record
ord-22478c799aa44c9886ca41bdf4ea6e13
Source dataset
uspto-grants-1999_07
Patent number
US05922726

Reaction notes

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