HCID 15818984, compound → HCID 15818985, compound

HRID 581840Notes

Reaction equation

HRID 581840 reaction equation
C([O:8][C:9]([CH2:11][CH2:12][CH:13]1[CH2:18][CH2:17][N:16]([CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:15][CH2:14]1)=[O:10])C1C=CC=CC=1>O1CCCC1.[Pd]>[C:9]([CH2:11][CH2:12][CH:13]1[CH2:18][CH2:17][N:16]([CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:15][CH2:14]1)([OH:10])=[O:8]

Participants

4

Reactant 1

HCID 15818984HCID 15818984, compound

Product 1

HCID 15818985HCID 15818985, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

10 g of 4-[2-(benzyloxycarbonyl)-ethyl]-1-[(ethoxycarbonyl)-methyl]-piperidine are hydrogenated in 150 ml of tetrahydrofuran at room temperature under a hydrogen pressure of 50 psi in the presence of 1.3 g of palladium-on-active charcoal for 4 hours. The solvent is evaporated off under reduced pressure and the residue is crystallized with diethyl ether and a little acetone.

Workup

  1. customfor 4 hours
  2. customThe solvent is evaporated off under reduced pressure
  3. customthe residue is crystallized with diethyl ether

Sources & evidence

ORD record
ord-76d52b071a0d446096ef0280a6f57188
Source dataset
uspto-grants-1999_07
Patent number
US05922717

Reaction notes

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