Lithium Hydroxide → HCID 178452058, compound

HRID 581842Notes

Reaction equation

HRID 581842 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:19][CH2:18][N:17]([C:20]([C@H:22]3[CH2:27][CH2:26][C@H:25]([C:28]([O:30]CC)=[O:29])[CH2:24][CH2:23]3)=[O:21])[CH2:16][CH2:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Li+]>C(Cl)Cl.CO>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:15][CH2:16][N:17]([C:20]([C@H:22]3[CH2:23][CH2:24][C@H:25]([C:28]([OH:30])=[O:29])[CH2:26][CH2:27]3)=[O:21])[CH2:18][CH2:19]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 178472379HCID 178472379, compound

Product 1

HCID 178452058HCID 178452058, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared from ethyl trans-4-[[-4-[1-(tert-butyloxycarbonyl)-piperidin-4-yl]-piperazin-1-yl]-carbonyl]-cyclohexane-carboxylate by hydrolysis with lithium hydroxide analogously to Example 24. Mass spectrum: (M+H)+ =424; Rf value: 0.24 (silica gel; methylene chloride/methanol/concentrated ammonia=4:1:0.2)

Sources & evidence

ORD record
ord-83c6fe1cd0fa4c558b65b7eb032a8bdc
Source dataset
uspto-grants-1999_07
Patent number
US05922717

Reaction notes

Loading…