Methanol → HCID 178501118, compound

HRID 581843Notes

Reaction equation

HRID 581843 reaction equation
[NH2:1][CH2:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([OH:11])=[O:10])[CH2:5][CH2:4]1.[CH3:12]O>Cl>[NH2:1][CH2:2][C@H:3]1[CH2:4][CH2:5][C@H:6]([C:9]([O:11][CH3:12])=[O:10])[CH2:7][CH2:8]1

Participants

4

Reactant 2

HCID 887MethanolHCID 178511262HCID 178511262, compound

Product 1

HCID 178501118HCID 178501118, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 15.7 g of trans-4-(aminomethyl)-cyclohexanecarboxylic acid in 150 ml of ethereal hydrochloric acid and 1000 ml of absolute methanol is stirred at room temperature for 20 hours. The solvent is evaporated off under reduced pressure and the residue is triturated with ether and filtered off with suction.

Workup

  1. customThe solvent is evaporated off under reduced pressure
  2. customthe residue is triturated with ether
  3. filtrationfiltered off with suction

Sources & evidence

ORD record
ord-cd63c4a4dcdf409f87b1e3f94366e5d1
Source dataset
uspto-grants-1999_07
Patent number
US05922717

Reaction notes

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