O-Methylhydroxylamine hydrochloride → HCID 87417072, compound

HRID 581922Notes

Reaction equation

HRID 581922 reaction equation
[CH:1]([C:3]1[CH:23]=[CH:22][C:6]2[N:7]([C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([C:16]4[CH:21]=[CH:20][N:19]=[CH:18][N:17]=4)[CH:11]=3)[CH:8]=[N:9][C:5]=2[CH:4]=1)=O.[NH2:24][O:25][CH3:26].Cl>>[CH3:26][O:25][N:24]=[CH:1][C:3]1[CH:23]=[CH:22][C:6]2[N:7]([C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([C:16]4[CH:21]=[CH:20][N:19]=[CH:18][N:17]=4)[CH:11]=3)[CH:8]=[N:9][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 539508245-Formyl-1-(3-(4-pyrimidyl)phenyl)benzimidazole

Product 1

HCID 87417072HCID 87417072, compoundYield 28.1%

Procedure

was synthesized as described in Example 22 but using (62) (200 mg, 0.66 mmol) instead of (55) and NH2OMe.HCl (250 mg, 2.0 mmol). The reaction gave (64) (61 mg, 28%). Mp. 180-182° C.

Workup

  1. customwas synthesized

Sources & evidence

ORD record
ord-3e944dcefd484bb68d56dd7699de8040
Source dataset
uspto-grants-1999_07
Patent number
US05922725

Reaction notes

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