反应详情

温度

45 °C

A mixture of 4-Fluoro-3-nitroacetophenone (5 g, 27.3 mmol) and 3-(3-pyridyl)aniline (4.62 g, 27.2 mmol) in dry 1-methyl-2-pyrrolidone (10 ml) is stirred at 40-50° C. overnight. The resulting solid reaction mixture is suspended in ice water (50 ml) and made alkaline by addition of 1 M NaHCO3. The product is filtered off, washed with water and dried to yield 7.68 g 4-acetyl-2-nitro-N-(3-(3-pyridyl)phenyl)aniline (85%).

1. customThe resulting solid reaction mixture
2. filtrationThe product is filtered off
3. washwashed with water
4. customdried