Ethanol → HCID 53793766, compound

HRID 582272Notes

Reaction equation

HRID 582272 reaction equation
[C:1]([O:5]CC)(=O)[CH:2]=[CH2:3].[Cl:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[NH:16][NH2:17].[O-]CC.[Na+].C(O)C>C1(C)C=CC=CC=1>[Cl:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[CH2:3][CH2:2][C:1](=[O:5])[NH:17]1

Participants

6

Reactant 4

HCID 702EthanolHCID 8821Ethyl AcrylateHCID 408929(2,4-Dichlorophenyl)hydrazineHCID 2723922Sodium ethoxide

Product 1

HCID 53793766HCID 53793766, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

105.0 g (1.05 mol) of ethyl acrylate is added dropwise to a mixture of 37.3 g (211 mmol) of 2,4-dichlorophenylhydrazine, 18.6 g (273 mmol) of sodium ethoxide, 150 ml of ethanol and 150 ml of toluene and the mixture is subsequently stirred for 1 hour. The reaction mixture is evaporated to 100 ml and the residue is taken up in water. The organic phase is separated off and extracted with 5% strength NaOH. The combined aqueous phases are adjusted to a pH of 6.5 and the solid formed is filtered off with suction, washed with water and dried under reduced pressure.

Workup

  1. customThe reaction mixture is evaporated to 100 ml
  2. customThe organic phase is separated off
  3. extractionextracted with 5% strength NaOH
  4. customthe solid formed
  5. filtrationis filtered off with suction
  6. washwashed with water
  7. customdried under reduced pressure

Sources & evidence

ORD record
ord-34b2a9f17ced415e99b406e2c111f7af
Source dataset
uspto-grants-1999_07
Patent number
US05922886

Reaction notes

Loading…