反应详情

温度

5 °C

4-[1-[3-(Isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]benzoic acid (1.5 g) was dissolved in methylene chloride (45 ml) and then, triethylamine (0.7 ml) was added and cooled. Pivaloyl chloride (0.58 ml) was added slowly to the solution at 0~5° C. and the mixture was stirred at 5° C. for 2 hours. N,N-Diisopropylethylamine (0.8 ml) and bis(2-methoxyethyl)amine (0.6 g) were added in order, the solution was stirred at 0~5° C. for 2 hours and heated slowly to 20~25° C. and stirred for 30 minutes. The reaction mixture was washed with water twice and with aqueous 5% sodium bicarbonate. Then, the solvent was dried over anhydrous sodium sulfate and the solvent was concentrated under reduced pressure. The concentrated residue was crystallized by treatment with ether and further recrystallized using ethyl acetate and ether. The recrystallized product was filtered and dried to give 1.65 g (yield: 84%) of the desired compound. m.p.: 82~83° C.; 1H-NMR(CDCl3), ppm: δ 1.21(d, 6H), 3.08(m, 4H), 3.25(s, 3H), 3.36(m, 5H), 3.52(m, 5H), 3.64(m, 2H), 3.74(m, 2H), 3.90(m, 2H), 4.15(m, 1H), 6.82(m, 1H), 6.91(m, 1H), 7.44(m, 4H), 7.66(m, 1H)

1. temperaturecooled
2. stirringthe solution was stirred at 0~5° C. for 2 hours
3. temperatureheated slowly to 20~25° C.
4. stirringstirred for 30 minutes
5. washThe reaction mixture was washed with water twice
6. dry with materialThen, the solvent was dried over anhydrous sodium sulfate
7. concentrationthe solvent was concentrated under reduced pressure
8. customThe concentrated residue was crystallized by treatment with ether
9. customfurther recrystallized
10. filtrationThe recrystallized product was filtered
11. customdried