HCID 19602468, compound → HCID 19602501, compound

HRID 582483Notes

Reaction equation

HRID 582483 reaction equation
[N:1]([CH2:4][CH:5]1[O:11][CH:10]2[N:7]([C:8](=[O:12])[CH2:9]2)[CH2:6]1)=[N+]=[N-].[H][H]>[Pd].C(OCC)(=O)C>[NH2:1][CH2:4][CH:5]1[O:11][CH:10]2[N:7]([C:8](=[O:12])[CH2:9]2)[CH2:6]1

Participants

5

Reactant 2

HCID 19602468HCID 19602468, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 19602501HCID 19602501, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

(3RS, 5SR)-3-azidomethyl-4-oxa-1-azabicyclo [3,2,0] heptan-7-one (150 mg, 0.89 mmol) was hydrogenated with 100 mg of 10% palladium on activated carbon in 25 ml of ethyl acetate at 50 psi hydrogen pressure at room temperature for 1 hr. After removal of catalyst by filtration, (3RS, 5SR)-3-aminomethyl-4-oxa-1-azabicyclo [3,2,0] heptan-7-one in ethyl acetate was obtained.

Workup

  1. customAfter removal of catalyst
  2. filtrationby filtration

Sources & evidence

ORD record
ord-d20e13dcc89d4ee0aaa59e43cfb9eafd
Source dataset
uspto-grants-1999_07
Patent number
US05925633

Reaction notes

Loading…