Potassium Cyanide → HCID 54456438, compound

HRID 582613Notes

Reaction equation

HRID 582613 reaction equation
C1(C)C=CC(S(O[CH2:11][CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[CH:19][CH:20]=[CH:21][C:15]=3[O:14]2)(=O)=O)=CC=1.[C-:23]#[N:24].[K+]>CS(C)=O>[C:23]([CH2:11][CH2:12][CH:13]1[CH2:17][C:16]2[CH:18]=[CH:19][CH:20]=[CH:21][C:15]=2[O:14]1)#[N:24]

Participants

4

Reactant 2

HCID 9032Potassium CyanideHCID 544699942-(2-Tosyloxyethyl)-2,3-dihydrobenzofuran

Product 1

HCID 54456438HCID 54456438, compoundYield 92.6%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Starting from 15.2 g (48 mmol) of 2-p-toluenesulfonyloxyethyl-2,3-dihydrobenzofuran (compound described in the U.S. Pat. No. 4,129,655) and 3.4 g (52 mmol) of potassium cyanide in 170 ml of dimethyl sulfoxide treated under the conditions described in step 5 of Example 7, 7.7 g of product were obtained in oil form.

Sources & evidence

ORD record
ord-eeecebefe8444e3d92f5801d1b46557b
Source dataset
uspto-grants-1999_07
Patent number
US05925662

Reaction notes

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