反应详情

A DMF solution (10 mL) of acid 6-4 (382 mg, 1.28 mmol) 1-4 (517 mg, 1.54 mmol), HOBT (264 mg, 1.13 mmol) NMM (563 μl, 5.1 mmol) and EDC (331 mg, 1.73 mmol) was stirred under ambient conditions for 18 h. The DMF was removed at 50° C. and the residue partitioned between EtOAc and H2O. The organic layer was washed with sat. NaHCO3 solution, brine, and dried (MgSO4). Evaporation gave a yellow foam which was purified by flash chromatography (silica, 3:1 acetone/CH2Cl2) to provide 6-5 as a colorless foam.

1. customThe DMF was removed at 50° C.
2. customthe residue partitioned between EtOAc and H2O
3. washThe organic layer was washed with sat. NaHCO3 solution, brine
4. dry with materialdried (MgSO4)
5. customEvaporation
6. customgave a yellow foam which
7. customwas purified by flash chromatography (silica, 3:1 acetone/CH2Cl2)