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HRID582910

反应详情

EQUATION

反应方程式

HRID 582910 的结构方程式

REACTANTS

反应物

4
结构：Cc1ccc(S(=O)(=O)O)cc1
HCID6101

4-Methylbenzenesulfonic acid

C7H8O3S

结构：COc1ccc(CO)cc1
HCID7738

(4-Methoxyphenyl)methanol

C8H10O2

结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：Cl.Nc1ccc(Cl)cc1C(=O)C(F)(F)F.O
HCID44181989

1-(2-Amino-5-chlorophenyl)-2,2,2-trifluoroethan-1-one--hydrogen chloride--water (1/1/1)

C8H8Cl2F3NO2

PRODUCTS

生成物

1
结构：COc1ccc(CNc2ccc(Cl)cc2C(=O)C(F)(F)F)cc1
HCID11089189

1-(5-Chloro-2-{[(4-methoxyphenyl)methyl]amino}phenyl)-2,2,2-trifluoroethan-1-one

C16H13ClF3NO2

AUXILIARIES

试剂、催化剂与溶剂

3
结构：O
溶剂HCID962

Water

H2O

结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

结构：Cc1ccccc1.O
溶剂HCID22272177

未命名化合物

PROCEDURE

实验过程

To a slurry of 4-Chloro-2-trifluoroacetylaniline, hydrochloride hydrate (40.0 kg, 144 mol) in toluene (140 kg) and water (50 L) was added 30% NaOH (18 kg) to pH 7.0. After removing the aqueous phase, 4-methoxybenzyl alcohol (20 kg, 144 mol) and TsOH (1.0 kg, 5.3 mol) were added. The solution was heated to reflux and the water/toluene azeotrope (30 L) distilled. The solution was cooled to room temperature and washed with saturated brine (80 kg).

WORKUP

后处理

  1. additionwere added
  2. temperatureThe solution was heated
  3. temperatureto reflux
  4. distillationdistilled
  5. washwashed with saturated brine (80 kg)