Triethylamine → N-(2,6-Dimethylcyclohex-1-yl)-1-(3-chloro-4-methylbenzyl)-5-(3,4-dichlorophenyl)pyrazole-3-carboxamide

HRID 582927Notes

Reaction equation

HRID 582927 reaction equation
Cl.[CH3:2][CH:3]1[CH2:8][CH2:7][CH2:6][CH:5]([CH3:9])[CH:4]1[NH2:10].C(N(CC)CC)C.[Cl:18][C:19]1[CH:20]=[C:21]([CH:39]=[CH:40][C:41]=1[CH3:42])[CH2:22][N:23]1[C:27]([C:28]2[CH:33]=[CH:32][C:31]([Cl:34])=[C:30]([Cl:35])[CH:29]=2)=[CH:26][C:25]([C:36](Cl)=[O:37])=[N:24]1>C(Cl)Cl>[CH3:2][CH:3]1[CH2:8][CH2:7][CH2:6][CH:5]([CH3:9])[CH:4]1[NH:10][C:36]([C:25]1[CH:26]=[C:27]([C:28]2[CH:33]=[CH:32][C:31]([Cl:34])=[C:30]([Cl:35])[CH:29]=2)[N:23]([CH2:22][C:21]2[CH:39]=[CH:40][C:41]([CH3:42])=[C:19]([Cl:18])[CH:20]=2)[N:24]=1)=[O:37]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 222509422,6-Dimethylcyclohexan-1-amine hydrochlorideHCID 540952651-(3-Chloro-4-methylbenzyl)-5-(3,4-dichlorophenyl)pyrazole-3-carboxylic acid chloride

Product 1

HCID 54139641N-(2,6-Dimethylcyclohex-1-yl)-1-(3-chloro-4-methylbenzyl)-5-(3,4-dichlorophenyl)pyrazole-3-carboxamideYield 32.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

This compound is prepared by the procedure described in step B of EXAMPLE 36 from 0.605 g of 2,6-dimethylcyclohexylamine hydrochloride, 1 ml of triethylamine in 15 ml of DCM and 1.5 g of the compound obtained in step A of EXAMPLE 36 in 15 ml of DCM. 0.6 g of the expected product is obtained; m.p.=59.9° C.

Workup

  1. customThis compound is prepared by the procedure

Sources & evidence

ORD record
ord-7cec936df46141748d1a055deabda09c
Source dataset
uspto-grants-1999_07
Patent number
US05925768

Reaction notes

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