反应详情

A solution of 4 g (34 mmol) of sodium dihydrogen phosphate in 40 ml of water and then 12.5 ml of 35% hydrogen peroxide solution were added at 10-15° C. to a solution of 40 g (125 mmol) of 4-chloro-3-(4-chloro-3-formylphenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole in 125 ml of acetonitrile. A solution of 18.1 g (200 mmol) of sodium chlorite in 158 ml of water was then added dropwise at 10° C. to the mixture. After stirring for one hour the mixture was acidified to pH 1 with 3N hydrochloric acid. The product then present in suspended form in the reaction mixture was separated off and recrystallized from methanol/water. Yield: 24.5 g.

1. customThe product then present in suspended form in the reaction mixture was separated off
2. customrecrystallized from methanol/water