Hydrochloric Acid → HCID 15220193, compound

HRID 583037Notes

Reaction equation

HRID 583037 reaction equation
P([O-])(O)(O)=O.[Na+].OO.[Cl:9][C:10]1[C:11]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[C:22]([CH:27]=[O:28])[CH:21]=2)=[N:12][N:13]([CH3:19])[C:14]=1[O:15][CH:16]([F:18])[F:17].Cl([O-])=[O:30].[Na+].Cl>O.C(#N)C>[C:27]([C:22]1[CH:21]=[C:20]([C:11]2[C:10]([Cl:9])=[C:14]([O:15][CH:16]([F:18])[F:17])[N:13]([CH3:19])[N:12]=2)[CH:25]=[CH:24][C:23]=1[Cl:26])([OH:30])=[O:28]

Participants

8

Reactant 5

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 152201894-Chloro-3-(4-chloro-3-formylphenyl)-5-difluoromethoxy-1-methyl-1H-pyrazoleHCID 23668197Sodium ChloriteHCID 23672064Monosodium phosphate

Product 1

HCID 15220193HCID 15220193, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 6342AcetonitrileSolvent

Procedure

A solution of 4 g (34 mmol) of sodium dihydrogen phosphate in 40 ml of water and then 12.5 ml of 35% hydrogen peroxide solution were added at 10-15° C. to a solution of 40 g (125 mmol) of 4-chloro-3-(4-chloro-3-formylphenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole in 125 ml of acetonitrile. A solution of 18.1 g (200 mmol) of sodium chlorite in 158 ml of water was then added dropwise at 10° C. to the mixture. After stirring for one hour the mixture was acidified to pH 1 with 3N hydrochloric acid. The product then present in suspended form in the reaction mixture was separated off and recrystallized from methanol/water. Yield: 24.5 g.

Workup

  1. customThe product then present in suspended form in the reaction mixture was separated off
  2. customrecrystallized from methanol/water

Sources & evidence

ORD record
ord-802aabb819e04a4f9acfb9ab997af2b3
Source dataset
uspto-grants-1999_07
Patent number
US05928999

Reaction notes

Loading…