Triethylamine → HCID 15220191, compound

HRID 583050Notes

Reaction equation

HRID 583050 reaction equation
C(N(CC)CC)C.[NH2:8][C:9]1[CH:10]=[C:11]([C:16]2[C:20]([Cl:21])=[C:19]([O:22][CH:23]([F:25])[F:24])[N:18]([CH3:26])[N:17]=2)[CH:12]=[CH:13][C:14]=1[Cl:15].[CH3:27][S:28](Cl)(=[O:30])=[O:29]>ClCCl>[Cl:21][C:20]1[C:16]([C:11]2[CH:12]=[CH:13][C:14]([Cl:15])=[C:9]([N:8]([S:28]([CH3:27])(=[O:30])=[O:29])[S:28]([CH3:27])(=[O:30])=[O:29])[CH:10]=2)=[N:17][N:18]([CH3:26])[C:19]=1[O:22][CH:23]([F:24])[F:25]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 21226443HCID 21226443, compound

Product 1

HCID 15220191HCID 15220191, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.3 g (22 mmol) of triethylamine were added to a solution of 3 g (10 mmol) of 3-(3-amino-4-chlorophenyl)-4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazole in 50 ml of dichloromethane. 2.5 g (21 mmol) of methanesulfonyl chloride were added dropwise to this mixture at 0° C. The reaction mixture was stirred at room temperature for 2 hours and then washed with water. The organic phase was subsequently dried over magnesium sulfate and concentrated. The solid product was washed with a little diethyl ether. Yield: 3.1 g.

Workup

  1. washwashed with water
  2. dry with materialThe organic phase was subsequently dried over magnesium sulfate
  3. concentrationconcentrated
  4. washThe solid product was washed with a little diethyl ether

Sources & evidence

ORD record
ord-bd9ffde8adc849fc9f4f1f2c768b0e9c
Source dataset
uspto-grants-1999_07
Patent number
US05928999

Reaction notes

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