反应详情

温度

-50 °C

2 Fluoronitrobenzene (20.0 g, 0.142 mol) was dissolved in dry tetrahydrofuran (400 ml) and cooled to -50° C. Vinylmagnesium chloride (288 ml, 15% wt/vol) was added at -45° C. and stirred at this temperature for one hour. Poured onto saturated ammonium chloride (600 ml). Separated and aqueous extracted with diethyl ether (2×200 ml). Dried (MgSO4), filtered and concentrated in vacuo to yield a dark oil which was purified by column chromatography on silica using toluene as mobile phase. Fractions concentrated to yield a crystalline solid.

1. customSeparated
2. extractionaqueous extracted with diethyl ether (2×200 ml)
3. dry with materialDried (MgSO4)
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customto yield a dark oil which
7. customwas purified by column chromatography on silica
8. concentrationFractions concentrated
9. customto yield a crystalline solid