Lithium Hydroxide → HCID 15860399, compound

HRID 583067Notes

Reaction equation

HRID 583067 reaction equation
[O:1]=[S:2]1(=[O:38])[N:7]([CH:8]([CH3:10])[CH3:9])[CH2:6][C:5]2[CH:11]=[C:12]([C:15]([O:17]CC)=[O:16])[CH:13]=[CH:14][C:4]=2[N:3]1[CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][C:25]([C:28]2[C:36]3[C:31](=[CH:32][C:33]([F:37])=[CH:34][CH:35]=3)[NH:30][CH:29]=2)=[CH:24][CH2:23]1.[OH-].[Li+]>O1CCCC1>[O:38]=[S:2]1(=[O:1])[N:7]([CH:8]([CH3:10])[CH3:9])[CH2:6][C:5]2[CH:11]=[C:12]([C:15]([OH:17])=[O:16])[CH:13]=[CH:14][C:4]=2[N:3]1[CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][C:25]([C:28]2[C:36]3[C:31](=[CH:32][C:33]([F:37])=[CH:34][CH:35]=3)[NH:30][CH:29]=2)=[CH:24][CH2:23]1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 70344745HCID 70344745, compound

Product 1

HCID 15860399HCID 15860399, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared from ethyl 3,4-dihydro-2,2-dioxo-1-{2-[4-(6-fluoroindol-3-yl)-1,2,5,6-tetrahydro-1-pyridyl]-1-ethyl}-3-(1-methylethyl)-1H-2,1,3-benzothiadiazine-6-carboxylate by lithium hydroxide hydrolysis in aqueous tetrahydrofuran, m.p. 192.8-194.4° C.

Sources & evidence

ORD record
ord-9ff12c0100a145aea7ee56658ffac7b8
Source dataset
uspto-grants-1999_07
Patent number
US05929072

Reaction notes

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