Hydrogen Bromide → Hydrochloric Acid

HRID 583129Notes

Reaction equation

HRID 583129 reaction equation
[CH2:1]([N:5]1[CH2:10][CH2:9][CH:8]([N:11]2[C:15](=[O:16])[O:14][C:13]([C:17]3[C:22]4[O:23][CH2:24][CH2:25][O:26][C:21]=4[C:20]([NH:27]C(=O)OCC4C=CC=CC=4)=[C:19]([Cl:38])[CH:18]=3)=[N:12]2)[CH2:7][CH2:6]1)[CH2:2][CH2:3][CH3:4].Br>C(O)C>[ClH:38].[NH2:27][C:20]1[C:21]2[O:26][CH2:25][CH2:24][O:23][C:22]=2[C:17]([C:13]2[O:14][C:15](=[O:16])[N:11]([CH:8]3[CH2:7][CH2:6][N:5]([CH2:1][CH2:2][CH2:3][CH3:4])[CH2:10][CH2:9]3)[N:12]=2)=[CH:18][C:19]=1[Cl:38].[ClH:38]

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 86754300HCID 86754300, compound

Product 2

HCID 313Hydrochloric AcidHCID 21310622HCID 21310622, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The preparation is carried out as described in Example 9.2, from phenylmethyl [8-[4-(1-butylpiperidin-4-yl)-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl]-6-chloro-2,3-dihydro-1,4-benzodioxin-5-yl]carbamate and hydrobromic acid, and the hydrochloride is formed by treatment with hydrochloric acid in ethanol. Melting point: 280-283° C.

Sources & evidence

ORD record
ord-4a18714bb39b42acbac174266fca01a7
Source dataset
uspto-grants-1999_07
Patent number
US05929089

Reaction notes

Loading…