Trifluoroacetic acid → (3-nitro-2-oxopyridin-1(2H)-yl)acetic acid

HRID 58317Notes

Reaction equation

HRID 58317 reaction equation
[N+:1]([C:4]1[C:5](=[O:18])[N:6]([CH2:10][C:11]([O:13]C(C)(C)C)=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].FC(F)(F)C(O)=O>ClCCl>[N+:1]([C:4]1[C:5](=[O:18])[N:6]([CH2:10][C:11]([OH:13])=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18989321tert-Butyl 3-nitro-2-oxo-1(2H)-pyridineacetate

Product 1

HCID 607739(3-nitro-2-oxopyridin-1(2H)-yl)acetic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3.73 g (14.7 mmol) of tert-butyl 2-(3-nitro-2-oxopyridin-1(2H)-yl)acetate are dissolved in 10 mL of dichloromethane and treated with 40 mL of trifluoroacetic acid. It is stirred at

Sources & evidence

ORD record
ord-04a2184d04ee4e7faef12ebbbf8e2be1
Source dataset
uspto-grants-2016_09
Patent number
US09434763B2

Reaction notes

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