HCID 53908716, compound → HCID 67637613, compound

HRID 583176Notes

Reaction equation

HRID 583176 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[CH2:30][CH2:29][C:7]2([O:11][CH2:10][C:9]([C:12]3[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[C:14]([N:20]4[C:24]([C:25]([F:28])([F:27])[F:26])=[N:23][N:22]=[N:21]4)[N:13]=3)=[CH:8]2)[CH:6]1[C:31]1[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=1)=[O:4]>CO.[OH-].[Pd+2].[OH-]>[CH3:1][O:2][C:3]([C@H:5]1[CH2:30][CH2:29][C@:7]2([O:11][CH2:10][C@H:9]([C:12]3[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[C:14]([N:20]4[C:24]([C:25]([F:28])([F:26])[F:27])=[N:23][N:22]=[N:21]4)[N:13]=3)[CH2:8]2)[C@@H:6]1[C:31]1[CH:32]=[CH:33][C:34]([F:37])=[CH:35][CH:36]=1)=[O:4]

Participants

4

Reactant 1

HCID 53908716HCID 53908716, compound

Product 1

HCID 67637613HCID 67637613, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

This material was made by hydrogenation with H2 in methanol over 20% palladium hydroxide of 6-(4-fluorophenyl)-3-[3-methoxy-6-(5-trifluoromethyl-tetrazol-1-yl)-pyridin-2-yl]-1-oxaspiro[4.4]non-3-ene-7-carboxylic acid methyl ester by the method given in Example 6, Step G. NMR (400 MHz, CDCl3): δ 7.66(d, J=7Hz,1H); 7.29(m, 3H); 6.90(t, J=9 Hz, 2H); 4.1(t, J=7Hz, 1H); 3.88 (s over multiplet, 3H+1H); 3.54(s,3H); 3.2-3.35(m, 3H); 2.25-2.33(m, 1H); 2.1-2.22(m, 3H); 1.90-2.0(m, 2H); Mass spectrum: 522 (M+1).

Sources & evidence

ORD record
ord-a49cc70768cf4032b6928a635bed8bc4
Source dataset
uspto-grants-1999_07
Patent number
US05929094

Reaction notes

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