HRID58328

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CN(CC(=O)NCCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1)/C(=N/C(=O)OC(C)(C)C)NC(=O)OC(C)(C)C.[Br-]

HCID178484700

未命名化合物

PRODUCTS

生成物

结构：CN(CC(=O)NCCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1)C(=N)[NH3+].O=C([O-])C(F)(F)F.O=C([O-])C(F)(F)F

HCID178484701

未命名化合物

收率 31%

PROCEDURE

实验过程

N2—{(E)-[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}-N2-methyl-N-[3-(triphenylphosphonio)propyl]glycinamide bromide (290 mg, 0.41 mmol) was dissolved in trifluoroacetic acid (1 ml, 10 mmol). After 20 minutes at room temperature, the volatiles were removed under vacuum, and the crude was purified with reverse phase preparative HPLC to give the title compound in a 31% yield.

WORKUP

后处理

customthe volatiles were removed under vacuum
customthe crude was purified with reverse phase preparative HPLC

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-781ca6147ec248809f64491715ba408e
来源数据集: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09434753B2
来源说明: uspto-grants-2016_09

反应 SMILES

C(OC([NH:8]/[C:9](=[N:38]\C(OC(C)(C)C)=O)/[N:10]([CH3:37])[CH2:11][C:12]([NH:14][CH2:15][CH2:16][CH2:17][P+:18]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:13])=O)(C)(C)C.[Br-].[F:47][C:48]([F:53])([F:52])[C:49]([OH:51])=[O:50]>>[F:47][C:48]([F:53])([F:52])[C:49]([O-:51])=[O:50].[F:47][C:48]([F:53])([F:52])[C:49]([O-:51])=[O:50].[NH3+:38][C:9](=[NH:8])[N:10]([CH3:37])[CH2:11][C:12]([NH:14][CH2:15][CH2:16][CH2:17][P+:18]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:13]