Aniline → Phenylurea

HRID 583549Notes

Reaction equation

HRID 583549 reaction equation
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:10]C1C=CC=CC=1>CN(C)C=O>[C:1]1([NH:7][C:8](=[O:9])[NH2:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 6115AnilineHCID 7672Phenyl isocyanate

Product 1

HCID 6145Phenylurea

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of phenyl isocyanate(1.0 equiv.) in dimethyl formamide (1 ml) the corresponding aniline (1.0 equiv.) was added. The reaction mixture was stirred at 80° C. until complete (3-16 hrs.), then removed solvent under vacuum. The purification, yields and spectral characteristics for each individual compound are listed below. Additional synthetic methods are provided for in PCT US96/02260 filed Feb. 16, 1996 whose disclosure is incorporated herein by reference.

Workup

  1. customThe purification
  2. customyields
  3. customAdditional synthetic methods are provided for in PCT US96/02260 filed Feb

Sources & evidence

ORD record
ord-bdefb34b0e984e35bfe8806f91580468
Source dataset
uspto-grants-1999_07
Patent number
US05929250

Reaction notes

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