反应详情

Bromide 23-2 (0.52 g, 2.14 mmol) and KCN (167 mg, 2.57 mmol) were combined in 10 mL DMSO. After 20 h, at RT and 1.5 h at 70° the reaction mixture was diluted with EtOAc, washed with water, sat. NaHCO3, 10 % KHSO4 and brine, dried (MgSO4), and concentrated providing 23-3 as a yellow solid. Rf 0.23 (30% EtOAc/hexanes).

1. washwashed with water, sat. NaHCO3, 10 % KHSO4 and brine
2. dry with materialdried (MgSO4)
3. concentrationconcentrated