Trifluoroacetic acid → 4-(Carboxymethoxy)-benzoic acid 1-methyl ester

HRID 583691Notes

Reaction equation

HRID 583691 reaction equation
C([O:5][CH2:6][C:7]([O:9][C:10]1[CH:19]=[CH:18][C:13]([C:14]([O:16][CH3:17])=[O:15])=[CH:12][CH:11]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=[O:21]>C(Cl)Cl>[C:6]([CH2:7][O:9][C:10]1[CH:19]=[CH:18][C:13]([C:14]([O:16][CH3:17])=[O:15])=[CH:12][CH:11]=1)([OH:5])=[O:21]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18928531Methyl 4-(t-butyloxyacetyloxy)benzoate

Product 1

HCID 138161514-(Carboxymethoxy)-benzoic acid 1-methyl ester

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Ester 24-1 was dissolved in 15 mL CH2Cl2, then 15 mL TFA was added. After 2 h, the mixture was concentrated providing 24-2 as a white solid.

Workup

  1. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-e833d6ddcd4f4fd9a9095b68559d58ac
Source dataset
uspto-grants-1999_07
Patent number
US05929120

Reaction notes

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