HRID583708

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)[C@H](CNC(=O)c1ccc(C=Cc2nc3ncccc3[nH]2)cc1)NS(=O)(=O)c1ccccc1

HCID86754341

未命名化合物

PRODUCTS

生成物

HCID86596525

Ethanol ammonium hydroxide water

C2H13NO3

结构：O=C(NC[C@H](NS(=O)(=O)c1ccccc1)C(=O)O)c1ccc(C=Cc2nc3ncccc3[nH]2)cc1

HCID86754342

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A CH2Cl2 solution (20 mL) of 31-4 (220 mg, 0.4 mmol) and TFA (5 mL) was stirred under ambient conditions for 5 h and concentrated. Flash chromatography (silica 9:0.5:0.5, EtOH/H2O/NH4OH) gave 31-5 as a solid.

WORKUP

后处理

concentrationconcentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4b8f46b968634e80b51a9c1b43d38d73
来源数据集: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05929120
来源说明: uspto-grants-1999_07

反应 SMILES

[C:1]([O:5][C:6](=[O:39])[C@@H:7]([NH:29][S:30]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)(=[O:32])=[O:31])[CH2:8][NH:9][C:10](=[O:28])[C:11]1[CH:16]=[CH:15][C:14]([CH:17]=[CH:18][C:19]2[NH:20][C:21]3[C:22]([N:27]=2)=[N:23][CH:24]=[CH:25][CH:26]=3)=[CH:13][CH:12]=1)(C)(C)[CH3:2].C(O)(C(F)(F)F)=[O:41]>C(Cl)Cl>[CH3:2][CH2:1][OH:5].[OH2:41].[NH4+:9].[OH-:5].[NH:20]1[C:21]2[C:22](=[N:23][CH:24]=[CH:25][CH:26]=2)[N:27]=[C:19]1[CH:18]=[CH:17][C:14]1[CH:13]=[CH:12][C:11]([C:10]([NH:9][CH2:8][C@H:7]([NH:29][S:30]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)(=[O:32])=[O:31])[C:6]([OH:39])=[O:5])=[O:28])=[CH:16][CH:15]=1