Trifluoroacetic acid → HCID 10255701, compound

HRID 583709Notes

Reaction equation

HRID 583709 reaction equation
C([O:5][C:6](=[O:40])[C@@H:7]([NH:30][S:31]([C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)(=[O:33])=[O:32])[CH2:8][NH:9][C:10](=[O:29])[C:11]1[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][C:19]2[N:28]=[C:27]3[C:22]([CH2:23][CH2:24][CH2:25][NH:26]3)=[CH:21][CH:20]=2)=[CH:13][CH:12]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH:26]1[C:27]2[C:22](=[CH:21][CH:20]=[C:19]([CH2:18][CH2:17][C:14]3[CH:15]=[CH:16][C:11]([C:10]([NH:9][CH2:8][C@H:7]([NH:30][S:31]([C:34]4[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=4)(=[O:32])=[O:33])[C:6]([OH:40])=[O:5])=[O:29])=[CH:12][CH:13]=3)[N:28]=2)[CH2:23][CH2:24][CH2:25]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 10603017HCID 10603017, compound

Product 1

HCID 10255701HCID 10255701, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 32-6 (221 mg, 0.39 mmol), TFA (5 mL) and CH2Cl2 (50 mL) was stirred under ambient conditions for 18 h. The reaction was concentrated and the solid residue purified by flash chromatography (silica, 19:1 EtOH/NH4OH) to give 32-7 as a pale yellow solid.

Workup

  1. concentrationThe reaction was concentrated
  2. customthe solid residue purified by flash chromatography (silica, 19:1 EtOH/NH4OH)

Sources & evidence

ORD record
ord-1f232eb1e7b8402b892956ec474103c3
Source dataset
uspto-grants-1999_07
Patent number
US05929120

Reaction notes

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