Trifluoroacetic acid → HCID 86752462, compound

HRID 583717Notes

Reaction equation

HRID 583717 reaction equation
C([O:5][C:6](=[O:42])[C@@H:7]([NH:32][S:33]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)(=[O:35])=[O:34])[CH2:8][NH:9][C:10](=[O:31])[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]2[NH:26][C:25]3[CH:27]=[CH:28][CH:29]=[CH:30][C:24]=3[N:23]=2)=[CH:13][CH:12]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH:23]1[C:24]2[CH:30]=[CH:29][CH:28]=[CH:27][C:25]=2[N:26]=[C:22]1[NH:21][CH2:20][CH2:19][CH2:18][O:17][C:14]1[CH:13]=[CH:12][C:11]([C:10]([NH:9][CH2:8][C@H:7]([NH:32][S:33]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)(=[O:34])=[O:35])[C:6]([OH:42])=[O:5])=[O:31])=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86752463HCID 86752463, compound

Product 1

HCID 86752462HCID 86752462, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A CH2Cl2 solution (20 mL) of 36-7 (580 mg, 0.97 mmol) and TFA (5 mL) was stirred under ambient conditions for 2 h and at 50° C. for 2 h. Concentration and flash chromatography (silica, 9:0.5:0.5 EtOH/H2O/NH4OH) gave 36-8 as a pale yellow solid.

Workup

  1. concentrationConcentration and flash chromatography (silica, 9:0.5:0.5 EtOH/H2O/NH4OH)

Sources & evidence

ORD record
ord-c680ec2700bf4a9a8ed50b22a2f1aad5
Source dataset
uspto-grants-1999_07
Patent number
US05929120

Reaction notes

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