1-Iodopropane → 4-(4-Chloro-3-trifluoromethyl-phenyl)-1-propyl-piperidine

HRID 584054Notes

Reaction equation

HRID 584054 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][C:3]=1[C:14]([F:17])([F:16])[F:15].[CH2:18](I)[CH2:19][CH3:20]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][N:11]([CH2:18][CH2:19][CH3:20])[CH2:10][CH2:9]2)=[CH:4][C:3]=1[C:14]([F:17])([F:15])[F:16]

Participants

3

Reactant 2

HCID 336431-IodopropaneHCID 166793174-[4-Chloro-3-(trifluoromethyl)phenyl]piperidine

Product 1

HCID 99046114-(4-Chloro-3-trifluoromethyl-phenyl)-1-propyl-piperidine

Procedure

Beginning with 4-(4-Chloro-3-trifluoromethyl-phenyl)-piperidine and 1-propyliodide, the title compound was re-covered by the procedure described in Example 2. m.p. 218-220° C. (HCl), MS m/z (rel. intensity, 70 eV) 305 (M+, 4), 278 (35), 277 (13), 276 (bp), 70 (40).

Sources & evidence

ORD record
ord-1d117724a1404b918824579f3281b741
Source dataset
uspto-grants-2005_08
Patent number
US06924374B2

Reaction notes

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