Hydrochloric Acid → cis-4-(3,4-Dichloro-phenyl)-2,6-dimethyl-1-propyl-piperazine

HRID 584077Notes

Reaction equation

HRID 584077 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([Cl:9])[CH:3]=1.[CH3:10][C@H:11]1[CH2:16][NH:15][CH2:14][C@@H:13]([CH3:17])[N:12]1[CH2:18][CH2:19][CH3:20].Cl>>[Cl:9][C:4]1[CH:3]=[C:2]([N:15]2[CH2:14][C@@H:13]([CH3:17])[N:12]([CH2:18][CH2:19][CH3:20])[C@@H:11]([CH3:10])[CH2:16]2)[CH:7]=[CH:6][C:5]=1[Cl:8]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 290134-Bromo-1,2-dichlorobenzeneHCID 28363798(2R,6S)-2,6-Dimethyl-1-propylpiperazine

Product 1

HCID 68444886cis-4-(3,4-Dichloro-phenyl)-2,6-dimethyl-1-propyl-piperazine

Procedure

Beginning with 4-bromo-1,2-dichlorobenzene and cis-2,6-dimethyl-1-propyl-piperazine, the title compound was recovered by the procedure described in Preparation 9: m.p. 225° C. (HCl), MS m/z (rel. intensity, 70 eV)) 301 (M+, 24), 271 (64), 112 (bp), 70 (47), 56 (53).

Workup

  1. customthe title compound was recovered by the procedure
  2. customdescribed in Preparation 9

Sources & evidence

ORD record
ord-762c182daf1343518215c56ff0ec539c
Source dataset
uspto-grants-2005_08
Patent number
US06924374B2

Reaction notes

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