Hydrazine hydrate (1:1) → HCID 22343040, compound

HRID 584114Notes

Reaction equation

HRID 584114 reaction equation
[CH3:1][C:2]1([CH3:16])[CH2:14][N:13]=[C:12]2[N:4]([C:5](=O)[C:6]3[C:11]2=[CH:10][CH:9]=[CH:8][CH:7]=3)[CH2:3]1.[OH2:17].[NH2:18][NH2:19]>CCO>[NH2:13][CH2:14][C:2]([CH3:16])([CH3:1])[CH2:3][NH:4][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:12](=[O:17])[NH:19][N:18]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 22343414HCID 22343414, compound

Product 1

HCID 22343040HCID 22343040, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 2,2-dimethyl-2,3-dihydro-1H-4,9a-diaza-fluoren-9-one (1.5 g, 7.0 mmol) in EtOH (17.5 mL), hydrazine hydrate (0.98 mL) was added and the mixture was heated at reflux for 3½ h. Crystallization provided 0.994 g (58%) of 4-(3-amino-2,2-dimethyl-propylamino)-2H-phthalazin-1-one.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 3½ h
  3. customCrystallization

Sources & evidence

ORD record
ord-e2428fae6eaf45a1a96fe7631cb4dd1d
Source dataset
uspto-grants-2005_08
Patent number
US06924284B2

Reaction notes

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