Succinic anhydride → HCID 22343117, compound

HRID 584120Notes

Reaction equation

HRID 584120 reaction equation
[C:1]1(=[O:7])[O:6][C:4](=[O:5])[CH2:3][CH2:2]1.[Cl:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([NH:15]O)=[NH:14])=[CH:11][N:10]=1>CN(C=O)C>[Cl:8][C:9]1[N:10]=[CH:11][C:12]([C:13]2[N:15]=[C:1]([CH2:2][CH2:3][C:4]([OH:6])=[O:5])[O:7][N:14]=2)=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 7922Succinic anhydrideHCID 178513305HCID 178513305, compound

Product 1

HCID 22343117HCID 22343117, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
120 °C

Procedure

Succinic anhydride (0.39 g, 3.89 mmol) and 6-chloro-N-hydroxy-nicotinamidine (0.67 g, 3.89 mmol) were dissolved in 2 mL of DMF and heated at 120° C. for 2 h. The cooled solution was filtered and the precipitate was washed with water, and dried to give the product as 0.70 g (71%) of colorless solid which was used without further purification.

Workup

  1. filtrationThe cooled solution was filtered
  2. washthe precipitate was washed with water
  3. customdried

Sources & evidence

ORD record
ord-290283f69cef4c44ad0dd7811f34642d
Source dataset
uspto-grants-2005_08
Patent number
US06924284B2

Reaction notes

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